Phospho-Ubiquitin: A Novel Biomarker for Neurodegenerative Diseases
11:30 am - Tuesday 1st December 2026
- Explore the biological role of phospho-ubiquitin (pUb) as an early marker of mitochondrial dysfunction, generated through activation of the PINK1/ Parkin pathway and linked to mitophagy and mitochondrial quality control in neurodegenerative diseases, particularly Parkinson’s disease
- Learn how novel TUBE-based assay technologies overcome the limitations of conventional phospho-ubiquitin detection methods, enabling sensitive and selective measurement of pUb and phospho-polyubiquitin species as potential blood-based biomarkers
- Understand the potential clinical applications of pUb biomarkers for earlier disease detection, patient stratification, target engagement assessment in clinical trials, and monitoring therapeutic responses across Parkinson’s disease and other neurodegenerative disorders
